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Rnlabs – L-5MTHF

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Features & Benefits

RN Labs L-5MTHF is a pure and highly bioavailable form of folate.

Directly facilitating methyl group donation in the body, L-5MTHF supports numerous metabolic processes for optimum healing, development, detoxification, mental health and wellbeing.

-Provides a methylated and metabolically active form of folate
-Bypasses the biochemical steps normally required by other folates
-Demonstrates greater metabolic activity than folic acid as a source of folate, with reduced potential for side effects
-Contributes to the normal growth of the foetus during pregnancy
-May support normal stress and cognitive function through healthy neurotransmitter production
-Supports healthy red blood cell formation
-Plays an important role in supporting healthy methylation
-Supports healthy homocysteine levels
-Supports healthy cardiovascular and vascular endothelial function

Dose & Administration

Suggested Use: Adults take 1 capsule daily or as prescribed by your healthcare practitioner.


Each Vegetarian Capsule Contains:
Levomefolate Calcium 550 micrograms
Equiv. Levomefolic acid (L-5MTHF) 500micrograms

Excipients: Leucine, Tapioca Starch, Microcrystalline Cellulose, Hypromellose (capsule), Colloidal Anhydrous Silica

Caution & Contradindications

If symptoms persist consult your healthcare practitioner.

Vitamin supplements should not replace a balanced diet.

Folate is considered safe during pregnancy.

Known Side Effects
In doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.

Whilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.

Medication Interactions
The activity of 5-MTHF may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.


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